The Amino Terminus of Slob, Slowpoke Channel Binding Protein, Critically Influences Its Modulation of the Channel
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The Amino Terminus of Slob, Slowpoke Channel Binding Protein, Critically Influences Its Modulation of the Channel
The Drosophila Slowpoke calcium-dependent potassium channel (dSlo) binding protein Slob was discovered by a yeast two-hybrid screen using the carboxy-terminal tail region of dSlo as bait. Slob binds to and modulates the dSlo channel. We have found that there are several Slob proteins, resulting from multiple translational start sites and alternative splicing, and have named them based on their ...
متن کاملSlob, a Slowpoke channel–binding protein, modulates synaptic transmission
Modulation of ion channels by regulatory proteins within the same macromolecular complex is a well-accepted concept, but the physiological consequences of such modulation are not fully understood. Slowpoke (Slo), a potassium channel critical for action potential repolarization and transmitter release, is regulated by Slo channel-binding protein (Slob), a Drosophila melanogaster Slo (dSlo) bindi...
متن کاملMechanisms of Two Modulatory Actions of the Channel-binding Protein Slob on the Drosophila Slowpoke Calcium-dependent Potassium Channel
Slob57 is an ion channel auxiliary protein that binds to and modulates the Drosophila Slowpoke calcium-dependent potassium channel (dSlo). We reported recently that residues 1-39 of Slob57 comprise the key domain that both causes dSlo inactivation and shifts its voltage dependence of activation to more depolarized voltages. In the present study we show that removal of residues 2-6 from Slob57 a...
متن کاملInnovative Methodology Expression and Function of Variants of Slob, Slowpoke Channel Binding Protein, in Drosophila
Jaramillo, Angela M., Haoyu Zeng, Hong Fei, Yi Zhou, and Irwin B. Levitan. Expression and function of variants of Slob, Slowpoke channel binding protein, in Drosophila. J Neurophysiol 95: 1957–1965, 2006. First published December 7, 2005; doi:10.1152/jn.00427.2005. Slob binds to and modulates the Drosophila Slowpoke (dSlo) calcium-activated potassium channel and also recruits the ubiquitous sig...
متن کاملExpression and function of variants of slob, slowpoke channel binding protein, in Drosophila.
Slob binds to and modulates the Drosophila Slowpoke (dSlo) calcium-activated potassium channel and also recruits the ubiquitous signaling protein 14-3-3 to the channel regulatory complex. RT-PCR reveals the presence of multiple slob transcripts in Drosophila heads. The transcripts are predicted to encode proteins that we call Slob51 (kDa), Slob57, Slob65, and Slob71. Slob51 and Slob65 are splic...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2005
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200509252